SEC16A Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. Belongs to the SEC16 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; organelle membrane; perinuclear region of cytoplasm
Molecular Function:  protein binding
Biological Process:  COPII vesicle coating; endoplasmic reticulum organization; ER to Golgi vesicle-mediated transport; Golgi to plasma membrane CFTR protein transport; protein exit from endoplasmic reticulum; protein localization to endoplasmic reticulum exit site; protein localization to plasma membrane; protein stabilization; response to endoplasmic reticulum stress
Reference #:  O15027 (UniProtKB)
Alt. Names/Synonyms: FLJ26737; KIAA0310; p250; pharbin; protein SEC16 homolog A; Protein transport protein Sec16A; SC16A; SEC16; SEC16 homolog A; SEC16L
Gene Symbols: SEC16A
Molecular weight: 251,894 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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