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PCBD2
Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity. Belongs to the pterin-4-alpha-carbinolamine dehydratase family. Note: This description may include information from UniProtKB.
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| Protein type: EC 4.2.1.96; Lyase; Oxidoreductase |
| Chromosomal Location of human Ortholog: 5q31.1 |
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Cellular Component:
nucleus
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Molecular Function:
4-alpha-hydroxytetrahydrobiopterin dehydratase activity; identical protein binding; phenylalanine 4-monooxygenase activity; protein binding
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Biological Process:
positive regulation of DNA-templated transcription; tetrahydrobiopterin biosynthetic process; tyrosine biosynthetic process, by oxidation of phenylalanine
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Reference #:
Q9H0N5
(UniProtKB)
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Alt. Names/Synonyms: 4-alpha-hydroxy-tetrahydropterin dehydratase 2; 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2; DcoH-like protein DCoHm; DCOH2; DCOHM; dimerization cofactor of hepatocyte nuclear factor 1 (HNF1) from muscle; dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); Dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor; PCBD2; PHS 2; PHS2; pterin-4 alpha-carbinolamine dehydratase 2; pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2; Pterin-4-alpha-carbinolamine dehydratase 2
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Gene Symbols: PCBD2
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Molecular weight:
14,365 Da
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Basal Isoelectric point:
9.17
Predict pI for various phosphorylation states
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