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FAM134B
Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons. Belongs to the RETREG family. Overexpressed in esophageal squamous cell carcinoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 5p15.1 |
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Cellular Component:
cis-Golgi network; endoplasmic reticulum; endoplasmic reticulum membrane; nuclear body; nucleolus
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Molecular Function:
endoplasmic reticulum-autophagosome adaptor activity; protein binding; protein self-association
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Biological Process:
collagen catabolic process; endoplasmic reticulum organization; mitophagy; negative regulation of neuron apoptotic process; reticulophagy; sensory perception of pain; white fat cell differentiation
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Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iia; Neuropathy, Hereditary Sensory And Autonomic, Type Iib
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Reference #:
Q9H6L5
(UniProtKB)
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Alt. Names/Synonyms: F134B; FAM134B; FAM134B protein; family with sequence similarity 134 member B; family with sequence similarity 134, member B; FLJ20152; FLJ22155; FLJ22179; JK-1; JK1; protein FAM134B; Reticulophagy receptor 1; reticulophagy receptor FAM134B; Reticulophagy regulator 1; RETR1; RETREG1
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Gene Symbols: RETREG1
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Molecular weight:
54,681 Da
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Basal Isoelectric point:
4.53
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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