PGAP1
Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Belongs to the GPI inositol-deacylase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.-.-; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Hydrolase; Lipase; Membrane protein, integral; Membrane protein, multi-pass |
Chromosomal Location of human Ortholog: 2q33.1 |
Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane
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Molecular Function:
hydrolase activity, acting on ester bonds; phosphatidylinositol deacylase activity
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Biological Process:
anterior/posterior axis specification; attachment of GPI anchor to protein; embryonic pattern specification; endoplasmic reticulum to Golgi vesicle-mediated transport; forebrain regionalization; GPI anchor metabolic process; positive regulation of ER to Golgi vesicle-mediated transport; protein transport; sensory perception of sound
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Disease: Mental Retardation, Autosomal Recessive 42
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Reference #:
Q75T13
(UniProtKB)
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Alt. Names/Synonyms: Bst1; FLJ42774; GPI deacylase; GPI inositol-deacylase; hPGAP1; ISPD3024; MRT42; PGAP1; post-GPI attachment to proteins 1; Post-GPI attachment to proteins factor 1; post-GPI attachment to proteins inositol deacylase 1; SPG67
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Gene Symbols: PGAP1
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Molecular weight:
105,383 Da
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Basal Isoelectric point:
9.14
Predict pI for various phosphorylation states
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