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MPSK1
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitously expressed at very low levels. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.2; EC 2.7.11.1; Kinase, protein; NAK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) |
| Chromosomal Location of rat Ortholog: 9q33 |
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Cellular Component:
cytosol; Golgi-associated vesicle; membrane; perinuclear region of cytoplasm
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Molecular Function:
ATP binding; DNA-binding transcription activator activity, RNA polymerase II-specific; non-membrane spanning protein tyrosine kinase activity; protein kinase activity; protein serine/threonine kinase activity
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Biological Process:
cellular response to transforming growth factor beta stimulus; peptidyl-tyrosine phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein phosphorylation
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Reference #:
P57760
(UniProtKB)
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Alt. Names/Synonyms: F52; MPSK; Mpsk1; Myristoylated and palmitoylated serine/threonine-protein kinase; PKL12; Protein kinase PKL12; serine/threonine kinase 16; Serine/threonine-protein kinase 16; Stk16; TGF-beta-stimulated factor 1; TSF-1; Tsf1
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Gene Symbols: Stk16
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Molecular weight:
34,409 Da
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Basal Isoelectric point:
5.99
Predict pI for various phosphorylation states
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