MPSK1 Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitously expressed at very low levels. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Kinase, protein; NAK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor)
Chromosomal Location of rat Ortholog: 9q33
Cellular Component:  cytosol; Golgi-associated vesicle; membrane; perinuclear region of cytoplasm
Molecular Function:  ATP binding; DNA-binding transcription activator activity, RNA polymerase II-specific; non-membrane spanning protein tyrosine kinase activity; protein kinase activity; protein serine/threonine kinase activity
Biological Process:  cellular response to transforming growth factor beta stimulus; peptidyl-tyrosine phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein phosphorylation
Reference #:  P57760 (UniProtKB)
Alt. Names/Synonyms: F52; MPSK; Mpsk1; Myristoylated and palmitoylated serine/threonine-protein kinase; PKL12; Protein kinase PKL12; serine/threonine kinase 16; Serine/threonine-protein kinase 16; Stk16; TGF-beta-stimulated factor 1; TSF-1; Tsf1
Gene Symbols: Stk16
Molecular weight: 34,409 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene