CK2A1 an ubiquitous protein kinase of the CK2 family. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. The isoforms are rarely specified in publications. Two splice variant isoforms have been found. Participates in Wnt signaling. Phosphorylates E2 ubiquitin conjugating enzyme UBC3B inducing its interaction with beta-TRCp and enhancing beta-catenin degradation. May control IkB-alpha and p27Kip1 degradation. component of a CK2-SPT16-SSRP1 complex composed of SSRP1, PT16 CK2-A1, CK2-A2 and CK2-B the complex associating following UV irradiation. Interacts with RNPS1. Mouse transgene causes mammary gland hyperplasia and lymphoma, and activation by bovine parasites leads to fatal lymphoproliferation. Expression and activity are elevated in lung tumors and breast tumors. Antisense drives apoptosis of tumor cell lines and xenografts. Involved in DNA break repair by phosphorylation of scaffold protein XRCC1, phosphorylation of BRCA1, and phosphorylation of p53 in response to UV irradiation. Drosophila CK2 (Timekeeper) is involved in circadian regulation. Phosphorylates and binds to a major component of the inclusion bodies seen in Parkinson?s patients. Inhibitors: 4,5,6,7-tetrabromobenzotriazole (TBB). Note: This description may include information from UniProtKB.
Protein type: CK2 family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 3q41
Cellular Component:  chromatin; cytoplasm; nucleoplasm; nucleus; NuRD complex; plasma membrane; protein kinase CK2 complex; Sin3 complex
Molecular Function:  ATP binding; beta-catenin binding; identical protein binding; kinase activity; protein N-terminus binding; protein phosphatase regulator activity; protein serine/threonine kinase activity; ribonucleoprotein complex binding
Biological Process:  apoptotic process; cerebral cortex development; liver regeneration; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of ubiquitin-dependent protein catabolic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of protein catabolic process; positive regulation of Wnt signaling pathway; protein autophosphorylation; protein phosphorylation; regulation of chromosome separation; regulation of protein localization to plasma membrane; response to testosterone; rhythmic process; Wnt signaling pathway
Reference #:  P19139 (UniProtKB)
Alt. Names/Synonyms: casein kinase 2, alpha 1 polypeptide; Casein kinase II subunit alpha; casein kinase II, alpha 1 polypeptide; CK II alpha; CSK21; Csnk2a1
Gene Symbols: Csnk2a1
Molecular weight: 45,073 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  NF-kB Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CK2A1

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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene