SBNO2 Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the proinflammatory cascade. Belongs to the SBNO family. Detected in macrophages. IL10 regulates expression in a STAT3-dependent way. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 19p13.3
Cellular Component:  nucleus
Molecular Function:  chromatin DNA binding; histone binding
Biological Process:  bone mineralization; bone trabecula morphogenesis; cellular response to interleukin-11; cellular response to interleukin-6; cellular response to leukemia inhibitory factor; cellular response to lipopolysaccharide; macrophage activation involved in immune response; negative regulation of DNA-templated transcription; osteoclast differentiation; osteoclast fusion; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of inflammatory response
Reference #:  Q9Y2G9 (UniProtKB)
Alt. Names/Synonyms: FLJ00173; KIAA0963; Protein strawberry notch homolog 2; SBNO2; SNO; STNO; strawberry notch homolog 2; strawberry notch homolog 2 (Drosophila)
Gene Symbols: SBNO2
Molecular weight: 150,275 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein