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SBNO2
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the proinflammatory cascade. Belongs to the SBNO family. Detected in macrophages. IL10 regulates expression in a STAT3-dependent way. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 19p13.3 |
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Cellular Component:
nucleus
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Molecular Function:
chromatin DNA binding; histone binding
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Biological Process:
bone mineralization; bone trabecula morphogenesis; cellular response to interleukin-11; cellular response to interleukin-6; cellular response to leukemia inhibitory factor; cellular response to lipopolysaccharide; macrophage activation involved in immune response; negative regulation of DNA-templated transcription; osteoclast differentiation; osteoclast fusion; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of inflammatory response
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Reference #:
Q9Y2G9
(UniProtKB)
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Alt. Names/Synonyms: FLJ00173; KIAA0963; Protein strawberry notch homolog 2; SBNO2; SNO; STNO; strawberry notch homolog 2; strawberry notch homolog 2 (Drosophila)
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Gene Symbols: SBNO2
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Molecular weight:
150,275 Da
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Basal Isoelectric point:
6.09
Predict pI for various phosphorylation states
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