SLC26A7 Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 4|4 A1
Cellular Component:  basolateral plasma membrane; cytoplasm; endosome; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  anion channel activity; anion transmembrane transporter activity; anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity; oxalate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; sulfate transmembrane transporter activity
Biological Process:  anion transport; bicarbonate transport; chloride transport; gastric acid secretion; ion transport; oxalate transport; sulfate transport; transmembrane transport
Reference #:  Q8R2Z3 (UniProtKB)
Alt. Names/Synonyms: Anion exchange transporter; anion exchanger Slc26a7; MGC30955; OTTMUSP00000004887; S26A7; Slc26a7; Solute carrier family 26 member 7; solute carrier family 26, member 7
Gene Symbols: Slc26a7
Molecular weight: 71,829 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene