|
SLC26A7
Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of Human Ortholog: 4|4 A1 |
|
Cellular Component:
basolateral plasma membrane; cytoplasm; endosome; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
|
|
Molecular Function:
anion channel activity; anion transmembrane transporter activity; anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity; oxalate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; sulfate transmembrane transporter activity
|
|
Biological Process:
anion transport; bicarbonate transport; chloride transport; gastric acid secretion; ion transport; oxalate transport; sulfate transport; transmembrane transport
|
|
Reference #:
Q8R2Z3
(UniProtKB)
|
|
Alt. Names/Synonyms: Anion exchange transporter; anion exchanger Slc26a7; MGC30955; OTTMUSP00000004887; S26A7; Slc26a7; Solute carrier family 26 member 7; solute carrier family 26, member 7
|
|
Gene Symbols: Slc26a7
|
|
Molecular weight:
71,829 Da
|
|
Basal Isoelectric point:
8.44
Predict pI for various phosphorylation states
|
