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SLC26A7
Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of mouse Ortholog: 4|4 A1 |
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Cellular Component:
apical plasma membrane; basolateral plasma membrane; cytoplasm; endosome; lateral plasma membrane; membrane; plasma membrane
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Molecular Function:
bicarbonate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity; chloride:bicarbonate antiporter activity; monoatomic anion channel activity; oxalate transmembrane transporter activity; sulfate transmembrane transporter activity
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Biological Process:
bicarbonate transport; chloride transport; gastric acid secretion; gluconate transmembrane transport; iodide transport; monoatomic anion transport; monoatomic ion transport; nitrate transmembrane transport; oxalate transport; sulfate transport; thyroid hormone generation; transmembrane transport
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Reference #:
Q8R2Z3
(UniProtKB)
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Alt. Names/Synonyms: Anion exchange transporter; anion exchanger Slc26a7; MGC30955; OTTMUSP00000004887; S26A7; Slc26a7; Solute carrier family 26 member 7; solute carrier family 26, member 7
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Gene Symbols: Slc26a7
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Molecular weight:
71,829 Da
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Basal Isoelectric point:
8.44
Predict pI for various phosphorylation states
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