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AT1
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Liver, lung, adrenal and adrenocortical adenomas. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of rat Ortholog: 17p12 |
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Cellular Component:
basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; dendrite; endosome; Golgi apparatus; organelle outer membrane; plasma membrane; recycling endosome
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Molecular Function:
angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; D1 dopamine receptor binding; protein binding; protein heterodimerization activity; protein kinase binding
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Biological Process:
activation of Janus kinase activity; angiotensin-activated signaling pathway; blood vessel development; brain renin-angiotensin system; calcium-mediated signaling; cell chemotaxis; cellular response to dexamethasone stimulus; dopamine biosynthetic process; drinking behavior; G protein-coupled receptor signaling pathway; gene expression; heart development; inflammatory response; kidney development; maintenance of blood vessel diameter homeostasis by renin-angiotensin; negative regulation of neuron apoptotic process; negative regulation of smooth muscle cell apoptotic process; neuron apoptotic process; phospholipase C-activating angiotensin-activated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of blood pressure; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of calcium ion import across plasma membrane; positive regulation of cell population proliferation; positive regulation of CoA-transferase activity; positive regulation of cytokine production; positive regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of macrophage derived foam cell differentiation; positive regulation of phospholipase A2 activity; positive regulation of protein metabolic process; positive regulation of receptor recycling; positive regulation of superoxide anion generation; positive regulation of vascular associated smooth muscle cell proliferation; regulation of blood pressure; regulation of pH; regulation of renal output by angiotensin; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; regulation of vascular associated smooth muscle cell apoptotic process; regulation of vasoconstriction; renin secretion into blood stream; renin-angiotensin regulation of aldosterone production; response to activity; response to angiotensin; response to corticosterone; response to estrogen; response to salt stress; Rho protein signal transduction; vascular associated smooth muscle cell proliferation; vasoconstriction
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Reference #:
P25095
(UniProtKB)
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Alt. Names/Synonyms: Agtr1; Agtr1a; AGTRA; angiotensin II receptor type 1; angiotensin II receptor, type 1a; Angiotensin II type-1A receptor; angiotensin receptor 1a; AT1; AT1A; AT1R; Type-1 angiotensin II receptor A; Type-1A angiotensin II receptor; vascular type-1 angiotensin II receptor
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Gene Symbols: Agtr1
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Molecular weight:
40,890 Da
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Basal Isoelectric point:
9.43
Predict pI for various phosphorylation states
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