STXBP1 Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Belongs to the STXBP/unc-18/SEC1 family. Brain and spinal cord. Highly enriched in axons. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of rat Ortholog: 3p11
Cellular Component:  axon; cytoplasm; cytoskeleton; cytosol; glutamatergic synapse; nucleoplasm; nucleus; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; platelet alpha granule; postsynapse; presynapse; presynaptic active zone membrane; protein-containing complex
Molecular Function:  identical protein binding; phospholipase binding; protein binding; protein domain specific binding; protein kinase binding; protein N-terminus binding; SNARE binding; syntaxin binding; syntaxin-1 binding
Biological Process:  axon target recognition; cellular response to interferon-gamma; developmental process involved in reproduction; exocytosis; long-term synaptic depression; negative regulation of neuron apoptotic process; negative regulation of protein complex assembly; negative regulation of SNARE complex assembly; negative regulation of synaptic transmission, GABAergic; neuromuscular synaptic transmission; neurotransmitter secretion; platelet aggregation; platelet degranulation; positive regulation of calcium ion-dependent exocytosis; positive regulation of exocytosis; positive regulation of glutamate secretion, neurotransmission; positive regulation of mast cell degranulation; positive regulation of vesicle docking; presynaptic dense core vesicle exocytosis; protein localization to plasma membrane; protein stabilization; protein transport; regulation of acrosomal vesicle exocytosis; regulation of synaptic vesicle priming; regulation of vesicle fusion; response to estradiol; SNARE complex assembly; synaptic vesicle maturation; synaptic vesicle priming; vesicle docking involved in exocytosis
Reference #:  P61765 (UniProtKB)
Alt. Names/Synonyms: ANC18HA; Munc18-1; N-Sec1; NSEC1A; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; rbSec1A; rbSec1B; Sec1; STXB1; Stxbp1; syntaxin binding protein 1; Syntaxin-binding protein 1; unc-18 homolog; unc-18-1; Unc-18A; Unc18-1; Unc18a
Gene Symbols: Stxbp1
Molecular weight: 67,569 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene