|
FAM83A iso3
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. Belongs to the FAM83 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 8q24.13 |
|
Cellular Component:
cytoplasm
|
|
Molecular Function:
identical protein binding; phosphatidylinositol 3-kinase regulatory subunit binding; protein binding; protein kinase binding
|
|
Biological Process:
cell population proliferation; epidermal growth factor receptor signaling pathway
|
|
Reference #:
Q86UY5-3
(UniProtKB)
|
|
Alt. Names/Synonyms: BJ-TSA-9; FA83A; FAM83A; FAM83A iso3; family with sequence similarity 83 member A; family with sequence similarity 83, member A; MGC14128; OTTHUMP00000228379; OTTHUMP00000228381; Protein FAM83A; Q86UY5-3; TSGP; Tumor antigen BJ-TSA-9; Tumor-specific gene expressed in prostate protein
|
|
Gene Symbols: FAM83A
|
|
Molecular weight:
40,576 Da
|
|
Basal Isoelectric point:
8.97
Predict pI for various phosphorylation states
|
