SLCO1C1 Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain. Belongs to the organo anion transporter (TC 2.A.60) family. Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 12p12.2
Cellular Component:  plasma membrane
Molecular Function:  thyroid hormone transmembrane transporter activity
Biological Process:  sodium-independent organic anion transport; thyroid hormone transport; transmembrane transport
Reference #:  Q9NYB5 (UniProtKB)
Alt. Names/Synonyms: OAT-RP-5; OATP-14; OATP-F; OATP1; OATP14; OATP1C1; OATPF; OATPRP5; Organic anion transporter F; Organic anion transporter polypeptide-related protein 5; organic anion transporting polypeptide 14; Organic anion-transporting polypeptide 14; SLC21A14; SLCO1C1; SO1C1; solute carrier family 21 (organic anion transporter), member 14; Solute carrier family 21 member 14; Solute carrier organic anion transporter family member 1C1; solute carrier organic anion transporter family, member 1C1; Thyroxine transporter
Gene Symbols: SLCO1C1
Molecular weight: 78,696 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB