ALG10 Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. Belongs to the ALG10 glucosyltransferase family. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of Human Ortholog: 12p11.1
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane
Molecular Function:  dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
Biological Process:  dolichol-linked oligosaccharide biosynthetic process
Disease: Long Qt Syndrome 2
Reference #:  Q5BKT4 (UniProtKB)
Alt. Names/Synonyms: AG10A; ALG10; ALG10 alpha-1,2-glucosyltransferase; ALG10A; Alpha-1,2-glucosyltransferase ALG10-A; Alpha-2-glucosyltransferase ALG10-A; alpha2-glucosyltransferase; asparagine-linked glycosylation 10 homolog (yeast, alpha-1,2-glucosyltransferase); asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog; asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe); Asparagine-linked glycosylation protein 10 homolog A; derepression of ITR1 expression 2 homolog; DIE2; Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase; FLJ14751; KCR1; potassium channel regulator 1
Gene Symbols: ALG10
Molecular weight: 55,606 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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