TSEN15 Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Belongs to the SEN15 family. Widely expressed. Highly expressed in testis and uterus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus
Chromosomal Location of Human Ortholog: 1q25.3
Cellular Component:  nucleolus; nucleoplasm
Molecular Function:  nucleic acid binding; tRNA-intron endonuclease activity
Biological Process:  mRNA processing; RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA splicing, via endonucleolytic cleavage and ligation
Disease: Pontocerebellar Hypoplasia, Type 2f
Reference #:  Q8WW01 (UniProtKB)
Alt. Names/Synonyms: C1orf19; HsSEN15; PCH2F; SEN15; SEN15 homolog; tRNA splicing endonuclease 15 homolog; tRNA splicing endonuclease 15 homolog (S. cerevisiae); tRNA splicing endonuclease subunit 15; tRNA-intron endonuclease Sen15; tRNA-splicing endonuclease subunit Sen15; TSEN15; TSEN15 tRNA splicing endonuclease subunit
Gene Symbols: TSEN15
Molecular weight: 18,641 Da
Basal Isoelectric point: 4.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein