PIK3R4 Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitously expressed. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, lipid; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); VPS15 family
Chromosomal Location of Human Ortholog: 9 F1|9 56.79 cM
Cellular Component:  axoneme; cytoplasmic vesicle; endosome; intracellular membrane-bounded organelle; late endosome; membrane; microtubule cytoskeleton; nucleus-vacuole junction; phosphatidylinositol 3-kinase complex, class III; phosphatidylinositol 3-kinase complex, class III, type I; phosphatidylinositol 3-kinase complex, class III, type II
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  autophagy of peroxisome; cellular response to glucose starvation; late endosome to vacuole transport; macroautophagy; phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; protein phosphorylation; protein targeting to vacuole; receptor catabolic process; regulation of cytokinesis
Reference #:  Q8VD65 (UniProtKB)
Alt. Names/Synonyms: 2210010O15Rik; C730038E05Rik; C85833; D9Ertd418e; p15; p150; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150; Phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase regulatory subunit 4; PI3-kinase regulatory subunit 4; PI3R4; Pik3r4; Vps15
Gene Symbols: Pik3r4
Molecular weight: 152,599 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  Autophagy Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PIK3R4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene