PIK3R4 Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitously expressed. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, lipid; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); VPS15 family
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component:  autophagosome; axoneme; cytosol; intracellular membrane-bounded organelle; late endosome; microtubule cytoskeleton; phagocytic vesicle membrane; phosphatidylinositol 3-kinase complex, class III
Molecular Function:  ATP binding; protein binding; protein kinase activity
Biological Process:  cellular response to glucose starvation; macroautophagy; phosphatidylinositol biosynthetic process; positive regulation of phosphatidylinositol 3-kinase activity; protein phosphorylation; receptor catabolic process; regulation of cytokinesis; toll-like receptor 9 signaling pathway
Reference #:  Q99570 (UniProtKB)
Alt. Names/Synonyms: MGC102700; p150; phosphatidylinositol 3-kinase-associated p150; Phosphoinositide 3-kinase adaptor protein; Phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; PI3R4; PIK3R4; VPS15
Gene Symbols: PIK3R4
Molecular weight: 153,103 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  Autophagy Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene