PIK3R4
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitously expressed. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.11.1; Kinase, lipid; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); VPS15 family |
Chromosomal Location of human Ortholog: 3q22.1 |
Cellular Component:
autophagosome; axoneme; cytosol; intracellular membrane-bounded organelle; late endosome; microtubule cytoskeleton; nucleus-vacuole junction; phagocytic vesicle membrane; phosphatidylinositol 3-kinase complex, class III; phosphatidylinositol 3-kinase complex, class III, type I; phosphatidylinositol 3-kinase complex, class III, type II
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Molecular Function:
ATP binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
autophagosome maturation; autophagy of peroxisome; cellular response to glucose starvation; early endosome to late endosome transport; late endosome to vacuole transport; macroautophagy; phosphatidylinositol 3-kinase signaling; phosphatidylinositol-3-phosphate biosynthetic process; protein phosphorylation; protein targeting to lysosome; protein targeting to vacuole; receptor catabolic process; regulation of autophagy; regulation of cytokinesis; regulation of macroautophagy
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Reference #:
Q99570
(UniProtKB)
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Alt. Names/Synonyms: MGC102700; p150; phosphatidylinositol 3-kinase-associated p150; Phosphoinositide 3-kinase adaptor protein; Phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; PI3R4; PIK3R4; VPS15
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Gene Symbols: PIK3R4
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Molecular weight:
153,103 Da
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Basal Isoelectric point:
6.74
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Adherens Junction Dynamics
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AMPK Signaling
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Angiogenesis
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Apoptosis Regulation
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Autophagy Signaling
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ErbB/HER Signaling
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ESC Pluripotency and Differentiation
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Growth And Differentiation Control by MAPKs
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IL6 Signaling
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Inhibition of Apoptosis
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Microtubule Dynamics
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Mitochondrial Control of Apoptosis
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mTOR Signaling
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NF-kB Signaling
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PI3K/Akt Signaling
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Protein Kinase C Signaling
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Translation: eIF4E and p70S6K
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Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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