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ULK4
May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Expressed in the brain, mainly in postmitotic neurons, including GABAergic neurons, but not in astrocytes (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); ULK family; ULK subfamily |
| Chromosomal Location of human Ortholog: 3p22.1 |
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Cellular Component:
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Molecular Function:
ATP binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
microtubule cytoskeleton organization; protein phosphorylation; regulation of JNK cascade; regulation of MAPK cascade; regulation of neuron migration; regulation of neuron projection development; regulation of p38MAPK cascade; regulation of protein kinase C signaling
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Reference #:
Q96C45
(UniProtKB)
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Alt. Names/Synonyms: DKFZp434E1822; FAM7C1; FLJ20574; REC01035; Serine/threonine-protein kinase ULK4; ULK4; unc-51 like kinase 4; Unc-51-like kinase 4; unc-51-like kinase 4 (C. elegans)
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Gene Symbols: ULK4
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Molecular weight:
142,442 Da
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Basal Isoelectric point:
5.9
Predict pI for various phosphorylation states
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