CTDSP2 Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver. Note: This description may include information from UniProtKB.
Protein type: EC; Nuclear receptor co-regulator; Phosphatase
Chromosomal Location of Human Ortholog: 12q14.1
Cellular Component:  nucleoplasm
Molecular Function:  metal ion binding; protein binding; RNA polymerase II CTD heptapeptide repeat phosphatase activity
Biological Process:  IRE1-mediated unfolded protein response; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of protein phosphorylation; protein dephosphorylation; regulation of transcription by RNA polymerase II
Reference #:  O14595 (UniProtKB)
Alt. Names/Synonyms: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; conserved gene amplified in osteosarcoma; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; CTD small phosphatase 2; CTDS2; CTDSP2; NIF2; NLI-interacting factor 2; Nuclear LIM interactor-interacting factor 2; OS4; Protein OS-4; PSR2; SCP2; Small C-terminal domain phosphatase 2; Small CTD phosphatase 2
Gene Symbols: CTDSP2
Molecular weight: 30,664 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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