PBK Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor); TOPK family
Chromosomal Location of mouse Ortholog: 14 D1|14 34.36 cM
Cellular Component:  nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cellular response to UV; mitotic cell cycle; negative regulation of inflammatory response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein phosphorylation; negative regulation of stress-activated MAPK cascade; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; protein phosphorylation
Reference #:  Q9JJ78 (UniProtKB)
Alt. Names/Synonyms: 2810434B10Rik; AW538537; CT84; D14Ertd732; D14Ertd732e; Lymphokine-activated killer T-cell-originated protein kinase; MAPKK-like protein kinase; Pbk; PDZ binding kinase; PDZ-binding kinase; T-LAK cell-originated protein kinase; Topk
Gene Symbols: Pbk
Molecular weight: 36,745 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene