PBK
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cancer Testis Antigen (CTA); EC 2.7.12.2; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor); TOPK family |
Chromosomal Location of mouse Ortholog: 14 D1|14 34.36 cM |
Cellular Component:
nucleus
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Molecular Function:
ATP binding; kinase activity; MAP kinase kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cellular response to UV; negative regulation of inflammatory response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein phosphorylation; negative regulation of stress-activated MAPK cascade; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; proteasome-mediated ubiquitin-dependent protein catabolic process; protein phosphorylation; stress-activated MAPK cascade
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Reference #:
Q9JJ78
(UniProtKB)
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Alt. Names/Synonyms: 2810434B10Rik; AW538537; CT84; D14Ertd732; D14Ertd732e; Lymphokine-activated killer T-cell-originated protein kinase; MAPKK-like protein kinase; Pbk; PDZ binding kinase; PDZ-binding kinase; T-LAK cell-originated protein kinase; Topk
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Gene Symbols: Pbk
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Molecular weight:
36,745 Da
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Basal Isoelectric point:
4.98
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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