CBX2 Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5). It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 11 E2|11 83.33 cM
Cellular Component:  chromosome; euchromatin; heterochromatin; nucleoplasm; nucleus; PcG protein complex; PRC1 complex
Molecular Function:  chromatin binding; DNA binding; methylated histone binding; protein binding
Biological Process:  chromatin organization; development of primary sexual characteristics; negative regulation of transcription by RNA polymerase II
Reference #:  P30658 (UniProtKB)
Alt. Names/Synonyms: Cbx2; chromobox homolog 2 (Drosophila Pc class); Chromobox protein homolog 2; hromobox homolog 2; M33; M33 polycomb-like protein; MOD2; Modifier 3 protein; OTTMUSP00000004311; pc; polycomb
Gene Symbols: Cbx2
Molecular weight: 54,918 Da
Basal Isoelectric point: 9.96  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene