RDH11
Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol. Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal. Has no dehydrogenase activity towards steroid. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cofactor and Vitamin Metabolism - retinol; EC 1.1.1.300; Membrane protein, integral; Oxidoreductase |
Chromosomal Location of mouse Ortholog: 12 C3|12 35.51 cM |
Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; membrane; photoreceptor inner segment; photoreceptor outer segment membrane
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Molecular Function:
aldehyde dehydrogenase (NADP+) activity; NADP-retinol dehydrogenase activity; oxidoreductase activity
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Biological Process:
adaptation of rhodopsin mediated signaling; cellular detoxification of aldehyde; lipid metabolic process; retinal metabolic process; retinoid metabolic process; retinol metabolic process; visual perception
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Reference #:
Q9QYF1
(UniProtKB)
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Alt. Names/Synonyms: 2610319N22Rik; AI428145; all-trans and 9-cis; Androgen-regulated short-chain dehydrogenase/reductase 1; Arsdr1; AU045252; C85936; cell line MC/9.IL4 derived transcript 1; Cell line MC/9.IL4-derived protein 1; CGI-82; HCBP12; M42C60; Mdt1; Prostate short-chain dehydrogenase/reductase 1; Psdr1; RalR1; Rdh11; Retinal reductase 1; Retinol dehydrogenase 11; SCALD; Short-chain aldehyde dehydrogenase; short-chain dehydrogenase/reductase 1; Ube-1c; UBE-1c1; ubiquitously expressing
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Gene Symbols: Rdh11
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Molecular weight:
35,148 Da
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Basal Isoelectric point:
9.1
Predict pI for various phosphorylation states
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