TRPM8
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: endoplasmic reticulum membrane; external side of plasma membrane; membrane raft; plasma membrane
Molecular Function: calcium channel activity; cation channel activity; identical protein binding; ligand-gated calcium channel activity; protein binding
Biological Process: calcium ion transmembrane transport; calcium-mediated signaling; cation transmembrane transport; cellular calcium ion homeostasis; detection of temperature stimulus; positive regulation of cold-induced thermogenesis; response to cold; thermoception
Alt. Names/Synonyms: Long transient receptor potential channel 6; LTrpC-6; LTRPC6; MGC2849; short form of the TRPM8 cationic channel; Transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel, subfamily M, member 8; Transient receptor potential p8; transient receptor potential subfamily M member 8; Trp-p8; TRPM8; TRPM8 cationic channel; TRPP8
