Slob Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. Belongs to the protein kinase superfamily. Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Slob family
Chromosomal Location of human Ortholog: 3p14.3
Cellular Component:  centriolar satellite; cytoplasm; cytosol; plasma membrane; protein-containing complex
Molecular Function:  actin binding; ATP binding; nucleotide binding; phosphatidylinositol binding; protein kinase activity
Biological Process:  inflammatory response; modulation of chemical synaptic transmission; negative regulation of ATP-dependent activity; negative regulation of ion transport; protein phosphorylation
Reference #:  Q7Z7A4 (UniProtKB)
Alt. Names/Synonyms: FLJ20335; Modulator of Na,K-ATPase; modulator of Na,K-ATPase long form; MONaKA; PX domain containing serine/threonine kinase; PX domain containing serine/threonine kinase like; PX domain-containing protein kinase-like protein; PX ser/thr kinase v2; PX serine/threonine kinase; PXK; Slob
Gene Symbols: PXK
Molecular weight: 64,950 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene