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PKDCC
is VLK, secreted tyr kinase
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| Protein type: EC 2.7.10.2; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, tyrosine (non-receptor); SgK493 family |
| Chromosomal Location of human Ortholog: 2p21 |
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Cellular Component:
extracellular region; Golgi apparatus
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Molecular Function:
ATP binding; non-membrane spanning protein tyrosine kinase activity; protein kinase activity
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Biological Process:
bone mineralization; cell differentiation; embryonic digestive tract development; limb morphogenesis; lung alveolus development; multicellular organism growth; negative regulation of Golgi to plasma membrane protein transport; peptidyl-tyrosine phosphorylation; positive regulation of bone mineralization; positive regulation of chondrocyte differentiation; protein transport; roof of mouth development; skeletal system development
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Disease: Rhizomelic Limb Shortening With Dysmorphic Features
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Reference #:
Q504Y2
(UniProtKB)
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Alt. Names/Synonyms: Extracellular tyrosine-protein kinase PKDCC; FLJ18197; MGC125960; PKDCC; protein kinase domain containing, cytoplasmic; protein kinase domain containing, cytoplasmic homolog; protein kinase domain containing, cytoplasmic homolog (mouse); Protein kinase domain-containing protein, cytoplasmic; Protein kinase-like protein SgK493; RLSDF; SGK493; Sugen kinase 493; Vertebrate lonesome kinase; VLK
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Gene Symbols: PKDCC
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Molecular weight:
54,132 Da
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Basal Isoelectric point:
8.76
Predict pI for various phosphorylation states
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