SCYL2 Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system. Belongs to the protein kinase superfamily. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); SCY1 family
Chromosomal Location of Human Ortholog: 10 C2|10 45.05 cM
Cellular Component:  cytoplasm; cytoplasmic vesicle; endosome; Golgi apparatus; membrane
Molecular Function:  ATP binding; protein binding; protein kinase activity; signaling receptor binding
Biological Process:  endosome to lysosome transport; negative regulation of canonical Wnt signaling pathway; positive regulation of clathrin-dependent endocytosis; positive regulation of receptor internalization; protein phosphorylation; receptor internalization involved in canonical Wnt signaling pathway
Reference #:  Q8CFE4 (UniProtKB)
Alt. Names/Synonyms: AU015688; AW536445; BC030932; Coated vesicle-associated kinase of 104 kDa; CVAK1; Cvak104; D10Ertd802; D10Ertd802e; SCY1-like 2 (S. cerevisiae); SCY1-like protein 2; Scyl2
Gene Symbols: Scyl2
Molecular weight: 103,317 Da
Basal Isoelectric point: 8.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene