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SCYL2
Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system. Belongs to the protein kinase superfamily. Note: This description may include information from UniProtKB.
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| Protein type: Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); SCY1 family |
| Chromosomal Location of human Ortholog: 12q23.1 |
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Cellular Component:
clathrin-coated vesicle; endosome membrane; Golgi apparatus
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Molecular Function:
ATP binding; protein binding; protein kinase activity; signaling receptor binding
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Biological Process:
brain development; endosome to lysosome transport; negative regulation of canonical Wnt signaling pathway; positive regulation of clathrin-dependent endocytosis; positive regulation of receptor internalization; protein phosphorylation; pyramidal neuron development; receptor internalization involved in canonical Wnt signaling pathway
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Disease: Arthrogryposis Multiplex Congenita, Neurogenic, With Agenesis Of The Corpus Callosum
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Reference #:
Q6P3W7
(UniProtKB)
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Alt. Names/Synonyms: AMC4; AMCNACC; Coated vesicle-associated kinase of 104 kDa; CVAK104; FLJ10074; KIAA1360; SCY1 like pseudokinase 2; SCY1-like 2; SCY1-like 2 (S. cerevisiae); SCY1-like protein 2; SCY1-like, kinase-like 2; SCYL2
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Gene Symbols: SCYL2
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Molecular weight:
103,709 Da
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Basal Isoelectric point:
8.45
Predict pI for various phosphorylation states
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