SCYL2 Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system. Belongs to the protein kinase superfamily. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); SCY1 family
Chromosomal Location of Human Ortholog: 12q23.1
Cellular Component:  clathrin-coated vesicle; endosome membrane; Golgi apparatus; perinuclear region of cytoplasm
Molecular Function:  ATP binding; protein binding; protein kinase activity; signaling receptor binding
Biological Process:  endosome to lysosome transport; negative regulation of canonical Wnt signaling pathway; positive regulation of clathrin-dependent endocytosis; positive regulation of receptor internalization; protein phosphorylation; receptor internalization involved in canonical Wnt signaling pathway
Disease: Arthrogryposis Multiplex Congenita, Neurogenic, With Agenesis Of The Corpus Callosum
Reference #:  Q6P3W7 (UniProtKB)
Alt. Names/Synonyms: AMC4; AMCNACC; Coated vesicle-associated kinase of 104 kDa; CVAK104; FLJ10074; KIAA1360; SCY1 like pseudokinase 2; SCY1-like 2; SCY1-like 2 (S. cerevisiae); SCY1-like protein 2; SCY1-like, kinase-like 2; SCYL2
Gene Symbols: SCYL2
Molecular weight: 103,709 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene