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MED23
Required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. Belongs to the Mediator complex subunit 23 family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 6q23.2 |
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Cellular Component:
core mediator complex; mediator complex; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
protein binding; transcription coactivator activity
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Biological Process:
positive regulation of gene expression; positive regulation of transcription elongation by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly; transcription initiation at RNA polymerase II promoter
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Disease: Mental Retardation, Autosomal Recessive 18
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Reference #:
Q9ULK4
(UniProtKB)
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Alt. Names/Synonyms: 130 kDa transcriptional co-activator; 133 kDa transcriptional co-activator; Activator-recruited cofactor 130 kDa component; ARC130; Cofactor required for Sp1 transcriptional activation subunit 3; cofactor required for Sp1 transcriptional activation, subunit 3 (130kD); cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; CRSP 130-kD subunit; CRSP complex subunit 3; CRSP130; CRSP133; CRSP3; DKFZp434H0117; DRIP130; hSur-2; KIAA1216; MED23; Mediator complex subunit 23; mediator complex subunit n23; Mediator of RNA polymerase II transcription subunit 23; mental retardation, non-syndromic, autosomal recessive, 18; MRT18; Protein sur-2 homolog; SUR-2; SUR2; transcriptional co-activator CRSP130; Transcriptional coactivator CRSP130; vitamin D3 receptor interacting protein; Vitamin D3 receptor-interacting protein complex 130 kDa component
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Gene Symbols: MED23
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Molecular weight:
156,474 Da
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Basal Isoelectric point:
7.09
Predict pI for various phosphorylation states
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