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SCYL1
Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro. Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. Belongs to the protein kinase superfamily. Ubiquitous. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); SCY1 family |
| Chromosomal Location of mouse Ortholog: 19 A|19 4.34 cM |
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Cellular Component:
cis-Golgi network; COPI vesicle coat; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum-Golgi intermediate compartment; Golgi apparatus
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Molecular Function:
ATP binding; protein binding; protein kinase activity
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Biological Process:
inflammatory response; neuron development; protein localization; protein phosphorylation; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; spinal cord motor neuron differentiation; vesicle-mediated transport
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Reference #:
Q9EQC5
(UniProtKB)
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Alt. Names/Synonyms: 105 kDa kinase-like protein; 2810011O19Rik; C85140; mdf; mfd; Mitosis-associated kinase-like protein NTKL; N-terminal kinase-like protein; Ntkl; p10; p105; SCY1-like 1 (S. cerevisiae); SCY1-like protein 1; Scyl1; ubiquitous protein kinase-like (105 kDa)
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Gene Symbols: Scyl1
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Molecular weight:
89,160 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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