RAMP2 Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family. Strongly expressed in lung, breast, immune system and fetal tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of human Ortholog: 17q21.2
Cellular Component:  adrenomedullin receptor complex; amylin receptor complex 2; cell surface; clathrin-coated pit; cytoplasm; lysosome; plasma membrane; receptor complex
Molecular Function:  adrenomedullin binding; adrenomedullin receptor activity; amylin receptor activity; coreceptor activity; protein binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adherens junction assembly; adrenomedullin receptor signaling pathway; amylin receptor signaling pathway; angiogenesis; basement membrane assembly; bicellular tight junction assembly; calcium ion transport; cellular response to hormone stimulus; cellular response to vascular endothelial growth factor stimulus; G protein-coupled receptor signaling pathway; heart development; intracellular protein transport; negative regulation of endothelial cell apoptotic process; negative regulation of vascular permeability; positive regulation of angiogenesis; positive regulation of gene expression; positive regulation of vasculogenesis; protein localization to plasma membrane; protein transport; receptor internalization; regulation of blood pressure; regulation of G protein-coupled receptor signaling pathway; sprouting angiogenesis; vascular associated smooth muscle cell development; vasculogenesis
Reference #:  O60895 (UniProtKB)
Alt. Names/Synonyms: calcitonin receptor-like receptor activity modifying protein 2; Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity-modifying protein 2; RAMP2; receptor (calcitonin) activity modifying protein 2; receptor (G protein-coupled) activity modifying protein 2; receptor activity modifying protein 2; Receptor activity-modifying protein 2; receptor-activity-modifying protein 2
Gene Symbols: RAMP2
Molecular weight: 19,608 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene