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RAMP2
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family. Strongly expressed in lung, breast, immune system and fetal tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: 17q21.2 |
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Cellular Component:
adrenomedullin receptor complex; amylin receptor complex 2; cell surface; clathrin-coated pit; cytoplasm; lysosome; plasma membrane; receptor complex
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Molecular Function:
adrenomedullin binding; adrenomedullin receptor activity; amylin receptor activity; coreceptor activity; protein binding
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; adherens junction assembly; adrenomedullin receptor signaling pathway; amylin receptor signaling pathway; angiogenesis; basement membrane assembly; bicellular tight junction assembly; calcium ion transport; cellular response to hormone stimulus; cellular response to vascular endothelial growth factor stimulus; G protein-coupled receptor signaling pathway; heart development; intracellular protein transport; negative regulation of endothelial cell apoptotic process; negative regulation of vascular permeability; positive regulation of angiogenesis; positive regulation of gene expression; positive regulation of vasculogenesis; protein localization to plasma membrane; protein transport; receptor internalization; regulation of blood pressure; regulation of G protein-coupled receptor signaling pathway; sprouting angiogenesis; vascular associated smooth muscle cell development; vasculogenesis
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Reference #:
O60895
(UniProtKB)
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Alt. Names/Synonyms: calcitonin receptor-like receptor activity modifying protein 2; Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity-modifying protein 2; RAMP2; receptor (calcitonin) activity modifying protein 2; receptor (G protein-coupled) activity modifying protein 2; receptor activity modifying protein 2; Receptor activity-modifying protein 2; receptor-activity-modifying protein 2
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Gene Symbols: RAMP2
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Molecular weight:
19,608 Da
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Basal Isoelectric point:
5.49
Predict pI for various phosphorylation states
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