SCYL1 Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro. Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. Belongs to the protein kinase superfamily. Ubiquitous. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); SCY1 family
Chromosomal Location of human Ortholog: 11q13.1
Cellular Component:  cis-Golgi network; COPI vesicle coat; cytoplasm; cytosol; endoplasmic reticulum-Golgi intermediate compartment; Golgi apparatus; microtubule organizing center; nucleus
Molecular Function:  ATP binding; DNA binding; protein tyrosine kinase activity
Biological Process:  peptidyl-tyrosine phosphorylation; retrograde vesicle-mediated transport, Golgi to ER
Disease: Spinocerebellar Ataxia, Autosomal Recessive 21
Reference #:  Q96KG9 (UniProtKB)
Alt. Names/Synonyms: Coated vesicle-associated kinase of 90 kDa; CVAK90; GKLP; HT019; likely ortholog of mouse N-terminal kinase-like protein; MGC78454; N-terminal kinase-like protein; NKTL; NTKL; P105; SCAR21; SCY1 like pseudokinase 1; SCY1-like 1 (S. cerevisiae); SCY1-like protein 1; SCY1-like, kinase-like 1; SCYL1; TAPK; TEIF; Telomerase regulation-associated protein; Telomerase transcriptional element-interacting factor; telomerase transcriptional elements-interacting factor; Teratoma-associated tyrosine kinase; TRAP
Gene Symbols: SCYL1
Molecular weight: 89,631 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein