RNASEL a multifunctional enzyme that possesses protein kinase and endoribonuclease activity, Mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA turnover. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.26.-; Kinase, protein; Other group; Other-Unique family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease
Chromosomal Location of Human Ortholog: 1q25.3
Cellular Component:  cytosol; mitochondrial matrix; nuclear matrix
Molecular Function:  ATP binding; endoribonuclease activity; metal ion binding; protein binding; protein kinase activity; ribonucleoprotein complex binding; RNA binding; rRNA binding
Biological Process:  defense response to virus; fat cell differentiation; mRNA processing; negative regulation of viral genome replication; positive regulation of glucose import; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of mRNA stability; regulation of type I interferon-mediated signaling pathway; RNA phosphodiester bond hydrolysis, endonucleolytic; rRNA processing; type I interferon signaling pathway
Disease: Prostate Cancer, Hereditary, 1
Reference #:  Q05823 (UniProtKB)
Alt. Names/Synonyms: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNase; DKFZp781D08126; interferon-induced 2-5A-dependent RNase; MGC104972; MGC133329; PRCA1; Ribonuclease 4; Ribonuclease L; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RN5A; RNase L; RNASEL; RNS4
Gene Symbols: RNASEL
Molecular weight: 83,533 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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