RNASEL Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis. Might play a central role in the regulation of mRNA turnover. Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length. Belongs to the protein kinase superfamily. Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.26.-; Kinase, protein; Other group; Other-Unique family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease
Chromosomal Location of human Ortholog: 1q25.3
Cellular Component:  cytosol; mitochondrial matrix; nuclear matrix
Molecular Function:  ATP binding; endoribonuclease activity; metal ion binding; protein binding; protein kinase activity; ribonucleoprotein complex binding; RNA binding; rRNA binding
Biological Process:  defense response to virus; fat cell differentiation; mRNA processing; negative regulation of viral genome replication; positive regulation of glucose import; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of mRNA stability; regulation of type I interferon-mediated signaling pathway; RNA phosphodiester bond hydrolysis, endonucleolytic; rRNA processing; type I interferon signaling pathway
Disease: Prostate Cancer, Hereditary, 1
Reference #:  Q05823 (UniProtKB)
Alt. Names/Synonyms: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNase; DKFZp781D08126; interferon-induced 2-5A-dependent RNase; MGC104972; MGC133329; PRCA1; Ribonuclease 4; Ribonuclease L; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RN5A; RNase L; RNASEL; RNS4
Gene Symbols: RNASEL
Molecular weight: 83,533 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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