SUMO3
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX. Belongs to the ubiquitin family. SUMO subfamily. Expressed predominantly in liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Ubiquitin-like modifier |
Chromosomal Location of human Ortholog: 21q22.3 |
Cellular Component:
cytoplasm; kinetochore; nucleoplasm; nucleus; PML body
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Molecular Function:
protein binding; protein tag activity; ubiquitin-like protein ligase binding
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Biological Process:
negative regulation of DNA binding; protein sumoylation; regulation of protein localization to nucleus
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Reference #:
P55854
(UniProtKB)
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Alt. Names/Synonyms: small ubiquitin like modifier 3; Small ubiquitin-related modifier 3; SMT3 homolog 1; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 3; SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae); SMT3A; Smt3B; SMT3H1; SUMO 3; SUMO-2; SUMO-3; SUMO3; Ubiquitin-like protein SMT3A; ubiquitin-like protein SMT3B
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Gene Symbols: SUMO3
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Molecular weight:
11,637 Da
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Basal Isoelectric point:
5.32
Predict pI for various phosphorylation states
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CST Pathways:
IL6 Signaling
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NF-kB Signaling
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Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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