KIS Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; KIS family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 1|1 H3
Cellular Component:  axon; cytoplasm; dendrite cytoplasm; intracellular membrane-bounded organelle; neuronal ribonucleoprotein granule; nuclear speck; nucleoplasm; nucleus
Molecular Function:  ATP binding; enzyme binding; kinase activity; nucleic acid binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; ribonucleoprotein complex binding; RNA binding; splicing factor binding; transferase activity
Biological Process:  neuron projection development; peptidyl-serine phosphorylation; phosphorylation; positive regulation of translational initiation; protein autophosphorylation; protein phosphorylation; regulation of cell cycle; regulation of protein export from nucleus
Reference #:  P97343 (UniProtKB)
Alt. Names/Synonyms: 4732477C12Rik; 4930500M09Rik; AA673513; AI449218; AU021979; C820018A03Rik; kinase interacting with leukemia-associated gene (stathmin); Kinase interacting with stathmin; Kis; Kist; OTTMUSP00000023989; P-CIP2; PAM COOH-terminal interactor protein 2; Serine/threonine-protein kinase Kist; U2AF homology motif (UHM) kinase 1; U2AF homology motif kinase 1; Uhmk1
Gene Symbols: Uhmk1
Molecular weight: 46,489 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein