|
KIS
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.7.11.1; KIS family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 1|1 H3 |
|
Cellular Component:
axon; cytoplasm; dendrite cytoplasm; intracellular membrane-bounded organelle; neuronal ribonucleoprotein granule; nuclear speck; nucleoplasm; nucleus
|
|
Molecular Function:
ATP binding; enzyme binding; kinase activity; nucleic acid binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; ribonucleoprotein complex binding; RNA binding; splicing factor binding; transferase activity
|
|
Biological Process:
neuron projection development; peptidyl-serine phosphorylation; phosphorylation; positive regulation of translational initiation; protein autophosphorylation; protein phosphorylation; regulation of cell cycle; regulation of protein export from nucleus
|
|
Reference #:
P97343
(UniProtKB)
|
|
Alt. Names/Synonyms: 4732477C12Rik; 4930500M09Rik; AA673513; AI449218; AU021979; C820018A03Rik; kinase interacting with leukemia-associated gene (stathmin); Kinase interacting with stathmin; Kis; Kist; OTTMUSP00000023989; P-CIP2; PAM COOH-terminal interactor protein 2; Serine/threonine-protein kinase Kist; U2AF homology motif (UHM) kinase 1; U2AF homology motif kinase 1; Uhmk1
|
|
Gene Symbols: Uhmk1
|
|
Molecular weight:
46,489 Da
|
|
Basal Isoelectric point:
5.59
Predict pI for various phosphorylation states
|
