KIS Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Other group; Other-Unique family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 1q23.3
Cellular Component:  axon; dendrite cytoplasm; Golgi apparatus; neuronal ribonucleoprotein granule; nucleoplasm; nucleus
Molecular Function:  ATP binding; protein binding; protein serine/threonine kinase activity; ribonucleoprotein complex binding; RNA binding; transferase activity
Biological Process:  cell cycle arrest; neuron projection development; peptidyl-serine phosphorylation; positive regulation of translational initiation; protein autophosphorylation; regulation of protein export from nucleus
Reference #:  Q8TAS1 (UniProtKB)
Alt. Names/Synonyms: kinase interacting stathmin; kinase interacting with leukemia-associated gene (stathmin); Kinase interacting with stathmin; KIS; KIS protein kinase; KIST; P-CIP2; PAM COOH-terminal interactor protein 2; Serine/threonine-protein kinase Kist; U2AF homology motif (UHM) kinase 1; U2AF homology motif kinase 1; UHMK1
Gene Symbols: UHMK1
Molecular weight: 46,546 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein