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ORP1
Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme. Expressed in retina. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, spleen and pancreas. Note: This description may include information from UniProtKB.
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| Protein type: Receptor, misc. |
| Chromosomal Location of mouse Ortholog: 1 A1|1 1.65 cM |
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Cellular Component:
axoneme; cell projection; ciliary tip; cilium; cytoplasm; cytoskeleton; microtubule associated complex; photoreceptor cell cilium; photoreceptor connecting cilium; photoreceptor inner segment; photoreceptor outer segment
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Molecular Function:
microtubule binding
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Biological Process:
axoneme assembly; cell projection organization; cellular response to light stimulus; intracellular signal transduction; microtubule polymerization; negative regulation of microtubule depolymerization; photoreceptor cell development; photoreceptor cell maintenance; photoreceptor cell outer segment organization; positive regulation of non-motile cilium assembly; response to stimulus; retina development in camera-type eye; retina morphogenesis in camera-type eye; retinal cone cell development; retinal rod cell development; visual perception
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Reference #:
P56716
(UniProtKB)
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Alt. Names/Synonyms: Dcdc3; Gm38717; lipoxygenase homology domain-containing protein 1; mG145; Orp1; Oxygen-regulated protein 1; retinitis pigmentosa 1 (human); retinitis pigmentosa 1 homolog; Retinitis pigmentosa RP1 protein homolog; Rp1; Rp1h
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Gene Symbols: Rp1
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Molecular weight:
234,388 Da
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Basal Isoelectric point:
7.4
Predict pI for various phosphorylation states
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