POMK Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily. Highest expression is observed in brain, skeletal muscle, kidney and heart in fetal and adult tissues. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Motility/polarity/chemotaxis; Other group; Other-Unique family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 8p11.21
Cellular Component:  endoplasmic reticulum membrane
Molecular Function:  ATP binding; carbohydrate kinase activity; phosphotransferase activity, alcohol group as acceptor; protein binding; protein kinase activity
Biological Process:  brain development; carbohydrate phosphorylation; learning or memory; neuromuscular process; protein O-linked glycosylation; protein phosphorylation; sensory perception of pain
Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 12; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 12
Reference #:  Q9H5K3 (UniProtKB)
Alt. Names/Synonyms: MDDGA12; MDDGC12; POMK; probable inactive protein kinase-like protein SgK196; Protein kinase-like protein SgK196; Protein O-mannose kinase; protein-O-mannose kinase; SG196; SGK196; Sugen kinase 196
Gene Symbols: POMK
Molecular weight: 40,050 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein