NSMCE4A
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. Belongs to the NSE4 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Chromosomal Location of human Ortholog: 10q26.13 |
Cellular Component:
chromosome, telomeric region; nuclear body; nucleoplasm; nucleus; Smc5-Smc6 complex
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Molecular Function:
protein binding
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Biological Process:
DNA damage response; DNA repair; double-strand break repair via homologous recombination; protein sumoylation; regulation of telomere maintenance
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Reference #:
Q9NXX6
(UniProtKB)
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Alt. Names/Synonyms: C10orf86; FLJ20003; Non-SMC element 4 homolog A; non-SMC element 4 homolog A (S. cerevisiae); Non-structural maintenance of chromosomes element 4 homolog A; NS4EA; NSE4 homolog A, SMC5-SMC6 complex component; NSE4 homolog, SMC5-SMC6 complex component A; NSE4A; NSMCE4A
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Gene Symbols: NSMCE4A
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Molecular weight:
44,301 Da
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Basal Isoelectric point:
5.25
Predict pI for various phosphorylation states
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