DSTYK Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin (PubMed:28157540). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Motility/polarity/chemotaxis; Other group; Other-Unique family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of mouse Ortholog: 1|1 E4
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cell junction; cytoplasm; membrane; plasma membrane
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  cellular response to fibroblast growth factor stimulus; negative regulation of apoptotic process; phosphorylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of kinase activity; protein phosphorylation
Reference #:  Q6XUX1 (UniProtKB)
Alt. Names/Synonyms: A930019K20Rik; C430014H23Rik; C820013G01; Dstyk; Dual serine/threonine and tyrosine protein kinase; DUSTY; Dusty PK; Dusty protein kinase; receptor interacting protein kinase 5; Receptor-interacting serine/threonine-protein kinase 5; Ripk5
Gene Symbols: Dstyk
Molecular weight: 104,901 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene