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DSTYK
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin (PubMed:28157540). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Dusty family; EC 2.7.12.1; Kinase, protein; Motility/polarity/chemotaxis; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) |
| Chromosomal Location of human Ortholog: 1q32.1 |
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Cellular Component:
anchoring junction; apical plasma membrane; basolateral plasma membrane; cytoplasm
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Molecular Function:
ATP binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
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Biological Process:
cellular response to fibroblast growth factor stimulus; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of kinase activity; protein phosphorylation
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Disease: Congenital Anomalies Of Kidney And Urinary Tract, Susceptibility To; Spastic Paraplegia 23
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Reference #:
Q6XUX3
(UniProtKB)
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Alt. Names/Synonyms: CAKUT1; DSTYK; Dual serine/threonine and tyrosine protein kinase; DUSTY; Dusty PK; Dusty protein kinase; DustyPK; HDCMD38P; KIAA0472; receptor interacting protein 5; receptor interacting protein kinase 5; Receptor-interacting serine/threonine-protein kinase 5; RIP-homologous kinase; RIP5; RIPK5; SGK496; spastic paraplegia 23 (autosomal recessive); SPG23; Sugen kinase 496
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Gene Symbols: DSTYK
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Molecular weight:
105,206 Da
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Basal Isoelectric point:
6.29
Predict pI for various phosphorylation states
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