DSTYK a serine/threonine protein kinase of the 'Other-Unique' family, most closely related to kinases of the TKL family including IRAK and RIPK. Overexpression induces apoptotic cell death. The caspase inhibitor crmA apparently blocks DNA fragmentation but not apoptosis, suggesting that SgK496 may induce both caspase-dependent apoptosis and caspase-independent cell death. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Motility/polarity/chemotaxis; Other group; Other-Unique family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cell junction; cytoplasm
Molecular Function:  ATP binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
Biological Process:  cellular response to fibroblast growth factor stimulus; negative regulation of apoptotic process; peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of kinase activity
Disease: Congenital Anomalies Of Kidney And Urinary Tract, Susceptibility To; Spastic Paraplegia 23
Reference #:  Q6XUX3 (UniProtKB)
Alt. Names/Synonyms: DSTYK; Dual serine/threonine and tyrosine protein kinase; DUSTY; Dusty PK; Dusty protein kinase; DustyPK; HDCMD38P; KIAA0472; receptor interacting protein 5; receptor interacting protein kinase 5; Receptor-interacting serine/threonine-protein kinase 5; RIP-homologous kinase; RIP5; RIPK5; SGK496; Sugen kinase 496
Gene Symbols: DSTYK
Molecular weight: 105,206 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein