TEX14 Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro. Belongs to the protein kinase superfamily. Expression restricted to testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); Kinase, protein; NKF5 family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 17q22
Cellular Component:  cell; condensed chromosome kinetochore; cytoplasm; intercellular bridge; kinetochore; midbody
Molecular Function:  ATP binding; protein binding; protein kinase activity; protein kinase binding
Biological Process:  attachment of spindle microtubules to kinetochore; cell division; cellular response to leukemia inhibitory factor; intercellular bridge organization; male meiotic nuclear division; mitotic sister chromatid separation; mitotic spindle assembly checkpoint; negative regulation of cytokinesis; negative regulation of protein binding; protein phosphorylation
Disease: Spermatogenic Failure 23
Reference #:  Q8IWB6 (UniProtKB)
Alt. Names/Synonyms: CT 113; Inactive serine/threonine-protein kinase TEX14; Protein kinase-like protein SgK307; SGK307; Sugen kinase 307; testis expressed 14; testis expressed sequence 14; Testis-expressed protein 14; Testis-expressed sequence 14; TEX14
Gene Symbols: TEX14
Molecular weight: 167,901 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein