GluR7 Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of human Ortholog: 1p34.3
Cellular Component:  axon; cell junction; dendrite; dendrite cytoplasm; glutamatergic synapse; integral component of plasma membrane; perikaryon; plasma membrane; terminal bouton
Molecular Function:  adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; glutamate receptor activity; ionotropic glutamate receptor activity; kainate selective glutamate receptor activity; ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
Biological Process:  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; G protein-coupled glutamate receptor signaling pathway; glutamate receptor signaling pathway; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; negative regulation of synaptic transmission, glutamatergic; regulation of membrane potential; regulation of postsynaptic membrane potential; regulation of presynaptic membrane potential
Reference #:  Q13003 (UniProtKB)
Alt. Names/Synonyms: dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); EAA5; Excitatory amino acid receptor 5; GLR7; GluK3; GluR-7; GLUR7; GluR7a; glutamate ionotropic receptor kainate type subunit 3; Glutamate receptor 7; Glutamate receptor ionotropic, kainate 3; Glutamate receptor, ionotropic kainate 3; glutamate receptor, ionotropic, kainate 3; GRIK3
Gene Symbols: GRIK3
Molecular weight: 104,037 Da
Basal Isoelectric point: 7.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene