PEAK1 Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling. Belongs to the protein kinase superfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; NKF3 family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 15q24.3
Cellular Component:  actin cytoskeleton; cytoplasm; focal adhesion
Molecular Function:  ATP binding; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity
Biological Process:  cell migration; focal adhesion assembly; protein autophosphorylation; protein phosphorylation; regulation of focal adhesion assembly; substrate adhesion-dependent cell spreading
Reference #:  Q9H792 (UniProtKB)
Alt. Names/Synonyms: FLJ21140; FLJ34483; Inactive tyrosine-protein kinase PEAK1; KIAA2002; NKF3 kinase family member; PEAK1; pseudopodium enriched atypical kinase 1; Pseudopodium-enriched atypical kinase 1; SG269; SGK269; Sugen kinase 269; Tyrosine-protein kinase SgK269
Gene Symbols: PEAK1
Molecular weight: 193,106 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PEAK1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein