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SGK223
Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth. Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism. Acts as a critical coactivator of Notch signaling. Belongs to the protein kinase superfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.2; Kinase, protein; Motility/polarity/chemotaxis; NKF3 family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 8 A4|8 22.78 cM |
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Cellular Component:
anchoring junction; cytoplasm; focal adhesion; nucleus
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Molecular Function:
ATP binding; identical protein binding; protein binding; protein kinase activity
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Biological Process:
cell migration; negative regulation of neuron projection development; positive regulation of Rho protein signal transduction; protein phosphorylation; regulation of cell motility; regulation of cell shape; regulation of Notch signaling pathway
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Reference #:
Q571I4
(UniProtKB)
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Alt. Names/Synonyms: 9830148H23; D8Ertd82; D8Ertd82e; DNA segment, Chr 8, ERATO Doi 82, expressed; FLJ00269; Inactive tyrosine-protein kinase PRAG1; mFLJ00269; MGC100334; NACK; Notch activation complex kinase; PEAK1 related kinase activating pseudokinase 1; PEAK1-related kinase-activating pseudokinase 1; Prag1; pragmin; SG223; Sgk223; Sugen kinase 223; tyrosine-protein kinase PRAG1; Tyrosine-protein kinase SgK223
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Gene Symbols: Prag1
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Molecular weight:
147,945 Da
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Basal Isoelectric point:
7.17
Predict pI for various phosphorylation states
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