AOF1
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Belongs to the flavin monoamine oxidase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Demethylase; EC 1.-.-.-; Oxidoreductase |
Chromosomal Location of human Ortholog: 6p22.3 |
Cellular Component:
nucleoplasm; nucleosome; nucleus
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Molecular Function:
chromatin binding; FAD binding; FAD-dependent H3K4me/H3K4me3 demethylase activity; flavin adenine dinucleotide binding; histone binding; histone demethylase activity; oxidoreductase activity; protein binding; transcription factor binding; zinc ion binding
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Biological Process:
genomic imprinting; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of gene expression by genomic imprinting
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Reference #:
Q8NB78
(UniProtKB)
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Alt. Names/Synonyms: amine oxidase (flavin containing) domain 1; amine oxidase, flavin containing 1; AOF1; bA204B7.3; C6orf193; dJ298J15.2; DKFZp686I0412; Flavin-containing amine oxidase domain-containing protein 1; FLJ33898; FLJ34109; FLJ43328; KDM1B; LSD2; lysine (K)-specific demethylase 1B; lysine demethylase 1B; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2
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Gene Symbols: KDM1B
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Molecular weight:
92,098 Da
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Basal Isoelectric point:
8.13
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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