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ALDH3B1
Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation. Belongs to the aldehyde dehydrogenase family. Highest expression in kidney and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.5; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 |
| Chromosomal Location of Human Ortholog: 1q43 |
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Cellular Component:
cytoplasm; cytosol; plasma membrane
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Molecular Function:
3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity
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Biological Process:
aldehyde catabolic process; cellular aldehyde metabolic process; cellular response to oxidative stress; ethanol catabolic process; oxidation-reduction process
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Reference #:
Q5XI42
(UniProtKB)
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Alt. Names/Synonyms: AL3B1; aldehyde dehydrogenase 3 family, member B1; Aldehyde dehydrogenase family 3 member B1; Aldh3b1; fatty aldehyde dehydrogenase-like; MGC95025
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Gene Symbols: Aldh3b1
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Molecular weight:
52,147 Da
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Basal Isoelectric point:
6.68
Predict pI for various phosphorylation states
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