ALDH3B1 Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation. Belongs to the aldehyde dehydrogenase family. Highest expression in kidney and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component:  cytoplasm; cytosol; plasma membrane; secretory granule membrane; specific granule membrane
Molecular Function:  aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; protein binding
Biological Process:  alcohol metabolic process; aldehyde catabolic process; cellular response to oxidative stress; ethanol catabolic process; lipid metabolic process; neutrophil degranulation; oxidation-reduction process; sphingolipid biosynthetic process
Reference #:  P43353 (UniProtKB)
Alt. Names/Synonyms: AL3B1; aldehyde dehydrogenase 3 family member B1; aldehyde dehydrogenase 3 family, member B1; aldehyde dehydrogenase 3B1; Aldehyde dehydrogenase 7; Aldehyde dehydrogenase family 3 member B1; ALDH3B1; ALDH4; ALDH7; FLJ26433; FLJ34710
Gene Symbols: ALDH3B1
Molecular weight: 51,840 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene