NEK11 Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Poorly expressed in cerebellum, trachea, lung, appendix, and uterus. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; NEK family; Nucleolus; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component:  nucleolus; nucleoplasm
Molecular Function:  ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  histone phosphorylation; intra-S DNA damage checkpoint; intracellular signal transduction; mitotic cell cycle phase transition; protein phosphorylation; regulation of mitotic cell cycle phase transition
Reference #:  Q8NG66 (UniProtKB)
Alt. Names/Synonyms: FLJ23495; NEK11; Never in mitosis A-related kinase 11; NIMA (never in mitosis gene a)- related kinase 11; NIMA related kinase 11; NIMA-related kinase 11; NimA-related protein kinase 11; Serine/threonine-protein kinase Nek11
Gene Symbols: NEK11
Molecular weight: 74,192 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein