RNF128 E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: Xq22.3
Cellular Component:  cytoskeleton; cytosol; integral component of membrane; perinuclear region of cytoplasm
Molecular Function:  metal ion binding; protein binding; ubiquitin protein ligase activity
Biological Process:  negative regulation of cytokine biosynthetic process; positive regulation of protein catabolic process in the vacuole; protein deubiquitination; protein localization to lysosome; protein ubiquitination; regulation of protein stability; ubiquitin-dependent protein catabolic process
Reference #:  Q8TEB7 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF128; FLJ23516; Gene related to anergy in lymphocytes protein; GRAIL; RING finger protein 128; ring finger protein 128, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF128; RN128; RNF128
Gene Symbols: RNF128
Molecular weight: 46,521 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RNF128

Protein Structure Not Found.


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