NEK9 Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts. Note: This description may include information from UniProtKB.
Protein type: Autophagy; EC 2.7.11.1; Kinase, protein; NEK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12|12 D1
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell division; phosphorylation; protein phosphorylation
Reference #:  Q8K1R7 (UniProtKB)
Alt. Names/Synonyms: C130021H08Rik; Nek9; Nercc; Nercc1 kinase; Never in mitosis A-related kinase 9; NIMA (never in mitosis gene a)-related expressed kinase 9; NimA-related protein kinase 9; Serine/threonine-protein kinase Nek9
Gene Symbols: Nek9
Molecular weight: 107,143 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
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NEK9

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene